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The Calcium Channel Blocker Gabapentin, a Benchmark Drug in Pain Studies, Inhibits Translocation of the Epsilon Isoform of Protein Kinase C in Cultured Nociceptors: A Novel Mechanism of Action

Gabapentin is a well-established anticonvulsant drug which is also effective for the treatment of neuropathic pain. Gabapentin, a structural analogue of the inhibitory neurotransmitter gamma-aminobutyric acid, was originally developed in the early nineties as a third-generation antiepileptic drug. Although the exact mechanism leading to relief of allodynia and hyperalgesia caused by neuropathy is not known, the blocking effect of gabapentin on voltage-dependent calcium channels has been propo...

Cone-Like Functional Properties of cGMP-Gated Channels in Rod-Like Retinal Photoreceptors of Nocturnal Geckoes

Retinas of nocturnal geckoes only contain scotopic photoreceptors with rod-shaped outer segments and sensitivities to light similar to the one of retinal rods from other species of lower vertebrates. However, these cells are not rods, but ” originally derived from cones in cone-only retinas of ancestral diurnal geckoes as a consequence of evolutionary pressure that forced adaptation to nocturnal behavior. Several interesting adaptations of these rod-like cones have been studied to date; molec...

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